Title: Postdoctoral fellow
Department: Surgery
School: School of Medicine
Location: Wolstein Research Building
Supervisor Name and Title: Jordan Winter, MD, Professor; Rui Wang, PhD, Assistant Professor
POSITION OBJECTIVE
We are highly translational laboratories study colorectal (CRC) and pancreatic (PC) cancers, with a focus in liver metastases and the tumor microenvironment (TME). Our laboratories have established strategies for isolating different human cell types from malignant and non-malignant surgical specimens. We use these primary cells, together with established cell lines, to understand how the tumor microenvironment promotes cancer cell survival pathways (growth, chemoresistance, metabolism ect.) with in vitro and in vivo models.
The candidate will lead on the projects to determine the effects of liver endothelial cells (EC), immune cells, and other TME cell types, on PC primary tumors and liver metastases. Lab work will involve tissue culture; patient tissue handling (cryo-preserving, isolating primary cells, developing organoids and PDXs); DNA, RNA, and protein-related assays; cell growth and death assays; animal work (xenograft tumor models, PDX, breeding). Additionally, studies will interface with experts in pathology, biostatistics, medicinal chemistry and other specialties. The candidate is expected to prepare manuscripts and contribute preliminary data, background and significance and experimental design for grant proposals. Under the guidance of the PIs, the candidate should be able to work independently, read and critically interpret the literature, assist with designing and planning of projects, oversee collaborations, supervise students, manage animal models, and to carry out research on the assigned project. The candidate is encouraged to apply for grants and present at local and national meetings. Importantly, the fellow must work well with others, and have a desire to help cancer patients as a principal motivation for their work.
ESSENTIAL FUNCTIONS
NONESSENTIAL FUNCTIONS
CONTACTS
PI: Continuous contact with Principal Investigators for mentorship and study designs
Lab colleagues: Continuous contact with lab members. Lab members are encouraged to help, and to ask for help.
Department: Moderate administrative staff contact to obtain administrative support for research activities.
University: Routine contact with Environmental Health and Safety, as well as Animal Research in order to meet regulatory requirements.
External: Regular contact with Collaborators to further our and their research objectives.
Students: Regular contact with graduate and undergraduate students as part of the teaching mission.
SUPERVISORY RESPONSIBILITY
Supervisory responsibilities principally will include mentorship of students in the lab.
QUALIFICATIONS
Experience: Graduate degree, in one of the fields related to biomedical and/or translational research, as preparation for a post-doctoral fellowship in cancer research.
Education/Licensing: PhD, MD, or equivalent.
REQUIRED SKILLS
WORKING CONDITIONS
The researcher will work at the bench performing experiments that requires standing and sitting. Will perform some experiments in the animal room, standing in the laminar flow hood. Involves walking between different buildings in the University. Will involve travel to meetings or conferences if secured travel funding. Must be willing to adjust working hours according to the nature of ongoing experiments.
DIVERSITY STATEMENT
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
For all applications, please directly contact the PIs at and , and send a copy of the updated CV.